Abstract |
Vinfunine (VFL) is a novel bifluorinated tubulin-targeted agent of the vinca alkaloids class active in advanced stage breast cancer. We conducted a phase I study combining VFL with doxorubicin (DXR) to define the recommended dose (RD), safety, pharmacokinetic (PK) interaction and efficacy. Two schedules (day 1 every 3 weeks; days 1 and 8 every 3 weeks) were investigated as first line chemotherapy in metastatic breast cancer patients. Thirty-two patients received a total of 162 cycles of the VFL-DXR combination (median 6). The RDs were VFL 250 mg/m(2)/DXR 40 mg/m(2) every 3 weeks for schedule 1 and VFL 120 mg/m(2)/DXR 25 mg/m(2) days 1 and 8 every 3 weeks for schedule 2. The main dose-limiting toxicity was neutropenia. The most frequent non-hematological adverse events were nausea, fatigue, constipation, vomiting, anorexia, stomatitis and dyspnea. Objective response rate was reached in 47.1% of the patients. No PK interaction was observed. VFL-DXR combination is feasible with manageable toxicity. The antitumor activity was promising and supports further evaluation.
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Authors | K Zaman, X Durando, J-F Baurain, Y Humblet, F Mazzeo, M Bostnavaron, N Meheust, S Monnoyer-Favrel, J-P Machiels, J Bauer |
Journal | Breast cancer research and treatment
(Breast Cancer Res Treat)
Vol. 127
Issue 3
Pg. 689-96
(Jun 2011)
ISSN: 1573-7217 [Electronic] Netherlands |
PMID | 21442199
(Publication Type: Clinical Trial, Phase I, Journal Article)
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Chemical References |
- vinflunine
- Vinblastine
- Doxorubicin
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Topics |
- Adolescent
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Breast Neoplasms
(drug therapy)
- Doxorubicin
(administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
- Drug Administration Schedule
- Female
- Humans
- Middle Aged
- Vinblastine
(administration & dosage, adverse effects, analogs & derivatives, pharmacokinetics, therapeutic use)
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