Abstract | BACKGROUND: Progressive macular hypomelanosis is a dermatosis without definite etiology. There is no consensus or first-line therapy in the treatment of progressive macular hypomelanosis, and the treatment options used are very little effective. OBJECTIVE: MATERIALS AND METHODS: This is a randomized, double-blind, placebo-controlled study in which patients were divided into two groups. Group A used the topical combination of benzoyl peroxide 5% and clindamycin 1% and Group B used gel cream as a placebo. Patients were advised to expose themselves to the sun on a daily basis and were systematically evaluated and photographed. The collected data were entered and analyzed using Epi Info. A p value < 0.05 was considered statistically significant. RESULTS: Out of the 23 patients included in the study, 13 were in group A and 10 in group B. Eleven patients (85%) in group A had significant clinical improvement and only two patients (20%) in group B showed an equivalent clinical improvement (p = 0.003). Side effects were more frequent in group A (p = 0.003). CONCLUSION:
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Authors | Jussamara Brito Santos, Olga Laura Sena Almeida, Lorena Marçal da Silva, Enio Ribeiro Maynard Barreto |
Journal | Anais brasileiros de dermatologia
(An Bras Dermatol)
2011 Jan-Feb
Vol. 86
Issue 1
Pg. 50-4
ISSN: 1806-4841 [Electronic] Spain |
PMID | 21437522
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Placebos
- Clindamycin
- Benzoyl Peroxide
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Topics |
- Administration, Topical
- Adult
- Age Factors
- Aged
- Benzoyl Peroxide
(therapeutic use)
- Clindamycin
(therapeutic use)
- Double-Blind Method
- Drug Therapy, Combination
(methods)
- Female
- Humans
- Hypopigmentation
(drug therapy)
- Male
- Middle Aged
- Placebos
(therapeutic use)
- Sex Factors
- Statistics, Nonparametric
- Treatment Outcome
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