Abstract | BACKGROUND: METHODS: Eighteen Caucasian CKD Stage 3a/3b patients with serum phosphate <4.5 mg/dL were recruited in a prospective longitudinal open-label study. Patients received a 4-week period of standardized phosphorus-restricted diet containing 0.8 g/Kg/day protein. Thereafter, the same diet was maintained and patients received lanthanum carbonate (750 mg with the three main meals) for 4 weeks. RESULTS: No significant changes were observed in serum phosphate, however, lanthanum carbonate significantly decreased urinary excretion of phosphate and fractional excretion of phosphate (P < 0.004). This was accompanied by a significant decrease in carboxyterminal FGF23 (median percent change from baseline -21.8% (interquartile range -4.5, -30%), P = 0.025). No changes were observed in PTH. CONCLUSIONS:
|
Authors | Emilio Gonzalez-Parra, Maria Luisa Gonzalez-Casaus, Antonio Galán, Alberto Martinez-Calero, Victor Navas, Mariano Rodriguez, Alberto Ortiz |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 26
Issue 8
Pg. 2567-71
(Aug 2011)
ISSN: 1460-2385 [Electronic] England |
PMID | 21436379
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- FGF23 protein, human
- Phosphorus
- lanthanum carbonate
- Fibroblast Growth Factors
- Lanthanum
- Fibroblast Growth Factor-23
|
Topics |
- Aged
- Female
- Fibroblast Growth Factor-23
- Fibroblast Growth Factors
(blood)
- Glomerular Filtration Rate
- Humans
- Kidney Failure, Chronic
(blood, drug therapy, pathology)
- Lanthanum
(pharmacology)
- Longitudinal Studies
- Male
- Phosphorus
(metabolism)
- Prognosis
- Prospective Studies
|