Abstract | OBJECTIVES: METHODS:
Pain was assessed by a Verbal Rating Scale (VRS). Whenever the VRS score was > or = 3, the patient was given a "rescue medication" ( tramadol 50 mg s.c.). The quality of life (time to return to normal daily activities, nightly rest, appetite, mood, deambulation, and self-care) was assessed in the postoperative period. Patients were asked to give their judgment on the surgical procedure and postoperative outcome. RESULTS: The results indicate that TP 37.5/325 mg was superior to CP 30/500 mg in terms of higher analgesic efficacy (VSR at 24 hours: CP 30/500, 2.52 +/- 0.86 vs. TP 37.5/325, 1.40 +/- 0.76; p < 0.001), less patients reporting adverse events (CP 30/500: 62% vs. TP 37.5/325: 36%; p < 0.01), less patients requiring rescue medications (CP 30/500: 18.2% vs. TP 37.5/325: 5.5%; p < 0.01), and more favorable judgment (scored "excellent" by 16% and 54.5% of CP 30/500 or TP 37.5/325-treated patients, respectively; p < 0.001). CONCLUSIONS: We conclude that a fixed association of tramadol/ paracetamol is a valuable and safe tool for pain management in day hospital surgery, especially whenever any effort is done to reduce the time for hospitalization.
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Authors | G Alfano, M Grieco, A Forino, G Meglio, M C Pace, M Iannotti |
Journal | European review for medical and pharmacological sciences
(Eur Rev Med Pharmacol Sci)
Vol. 15
Issue 2
Pg. 205-10
(Feb 2011)
ISSN: 1128-3602 [Print] Italy |
PMID | 21434488
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Acetaminophen
- Tramadol
- Codeine
|
Topics |
- Acetaminophen
(administration & dosage, therapeutic use)
- Adult
- Aged
- Ambulatory Surgical Procedures
- Analgesia
- Codeine
(administration & dosage, therapeutic use)
- Drug Therapy, Combination
- Female
- Humans
- Male
- Middle Aged
- Pain, Postoperative
(drug therapy)
- Tramadol
(administration & dosage, therapeutic use)
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