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Efficacy comparison of oral steroid, intratympanic steroid, hyperbaric oxygen and oral steroid + hyperbaric oxygen treatments in idiopathic sudden sensorineural hearing loss cases.

Abstract
Idiopathic sudden sensorineural hearing loss is a rare disorder of unknown pathogenesis in which hearing is lost partially or totally. About 60 treatment modalities have been described. We aimed to compare the efficacy of hyperbaric oxygen, oral steroid, intratympanic steroid therapy and their combinations in idiopathic sudden sensorineural hearing loss patients. Files of patients who were followed up between 2004 and 2010 in our clinic were examined retrospectively. Patients were divided into four groups according to the therapy received: Oral steroid, oral steroid + hyperbaric oxygen, intratympanic steroid and hyperbaric oxygen. Treatment success was assessed by Siegel criteria and mean gains using pre-treatment and post-treatment audiograms. 217 patients and 219 ears were examined. The proportion of patients responding to therapy was the highest in the oral steroid + hyperbaric oxygen group with 86.88% (53/61) followed by the oral steroid group with 63.79% (37/58), the intratympanic steroid group with 46,51% (20/43) and the hyperbaric oxygen group with 43.85% (25/57). The proportion of patients who had complete recovery was the highest in the oral steroid + hyperbaric oxygen group with 42.6% (26/61) followed by the oral steroid group with 19.0% (11/58), the hyperbaric oxygen group with 17.5% (10/57) and the intratympanic steroid group with 11.6% (5/43). The oral steroid + hyperbaric oxygen group has the highest mean hearing gain among all groups (p < 0.05). Idiopathic sudden sensorineural hearing loss patients receiving oral steroid + hyperbaric oxygen combination therapy have a higher likelihood of recovery than patients receiving oral steroids, hyperbaric oxygen or intratympanic steroids alone.
AuthorsYalcin Alimoglu, Ender Inci, Deniz Tuna Edizer, Alper Ozdilek, Mehmet Aslan
JournalEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (Eur Arch Otorhinolaryngol) Vol. 268 Issue 12 Pg. 1735-41 (Dec 2011) ISSN: 1434-4726 [Electronic] Germany
PMID21431435 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Glucocorticoids
Topics
  • Administration, Oral
  • Administration, Topical
  • Audiometry
  • Follow-Up Studies
  • Glucocorticoids (administration & dosage)
  • Hearing
  • Hearing Loss, Sensorineural (diagnosis, physiopathology, therapy)
  • Hearing Loss, Sudden (diagnosis, physiopathology, therapy)
  • Humans
  • Hyperbaric Oxygenation (methods)
  • Recovery of Function (physiology)
  • Retrospective Studies
  • Treatment Outcome
  • Tympanic Membrane

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