Abstract | BACKGROUND: Enzymatic and nonenzymatic oxidation of polyunsaturated fatty acids leads to the formation of biologically active products known as lipid mediators. In the brain, lipid mediators play an important role in supporting homeostasis and normal function. Thus, levels of these metabolites in normal and pathologic conditions in the brain are particularly relevant in understanding the transition to disease. METHODS: In this study, liquid chromatography tandem mass spectrometry was used to analyze lipid mediators in cerebrospinal fluid (CSF) of controls and traumatic brain injured (TBI) patients. RESULTS: CONCLUSIONS: This study clearly shows that certain lipid mediators accumulate in the CSF of TBI patient. This study also suggests the potential use of DHA, AA, 5- and 12-HETE as biochemical markers of brain injury and to monitor the impact of interventions.
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Authors | Santiago E Farias, Kim A Heidenreich, Max V Wohlauer, Robert C Murphy, Ernest E Moore |
Journal | The Journal of trauma
(J Trauma)
Vol. 71
Issue 5
Pg. 1211-8
(Nov 2011)
ISSN: 1529-8809 [Electronic] United States |
PMID | 21427623
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Biomarkers
- Hydroxyeicosatetraenoic Acids
- Docosahexaenoic Acids
- Arachidonic Acid
- 5-hydroxy-6,8,11,14-eicosatetraenoic acid
- 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
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Topics |
- 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
(cerebrospinal fluid)
- Adult
- Arachidonic Acid
(cerebrospinal fluid)
- Biomarkers
(cerebrospinal fluid)
- Brain Injuries
(cerebrospinal fluid)
- Case-Control Studies
- Chromatography, Liquid
- Docosahexaenoic Acids
(cerebrospinal fluid)
- Female
- Humans
- Hydroxyeicosatetraenoic Acids
(cerebrospinal fluid)
- Male
- Middle Aged
- Tandem Mass Spectrometry
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