[Rheumatism and acne conglobata . Apropos of a new case, in a 13-year-old boy].

Abstract

With reference to a new case of acne conglobata-associated rheumatic disease in a thirteen-year-old boy, we recall the characteristics of the main joint and/or bone manifestations that may occur during severe flares of acne conglobata, but also acne fulminans or pustulosis of the palms and soles. Joint manifestations mainly involve the large proximal joints of the limbs and consist in pain rather than in signs of inflammation. Although recurrences may develop, joint disease responds to treatment of the acne combined with a non-steroidal antiinflammatory drug. Bone involvement consists in true rheumatic osteitis with hyperostosis responsible for densification and thickening of bone, mainly in the anterior chest wall and spine. The pathogenesis and nosologic place of these bone and joint manifestations remain controversial: they do not seem to represent true reactive arthritis and, although the B27 antigen is usually lacking, they have been likened to the group of spondylarthropathies, especially in those cases with sacroiliac involvement and enthesopathy . Oddly enough, they are reminiscent of some of the side effects of etretinate, an agent prescribed in these severe forms of acne. After a national survey carried out in 1986, the acronym SAPHO (Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis) was suggested to designate the range of skin, bone and joint manifestations observed.

• Authors: H Konczaty, A Bourrillon, F Hayem
• Journal: Annales de pediatrie (Ann Pediatr (Paris)) Vol. 37 Issue 4 Pg. 231-4 (Apr 1990) ISSN: 0066-2097 [Print] France
• Vernacular Title: Le rhumatisme de l'acné conglobata. A propos d'une nouvelle observation, chez un garçon de treize ans.
• PMID: 2142387 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Etretinate

Topics

• Acne Vulgaris (complications, drug therapy)
• Adolescent
• Arthritis, Rheumatoid (chemically induced, etiology)
• Etretinate (adverse effects)
• Humans
• Male