Wilms tumor: five-year tumor-free survival on a modified SIOP protocol from an Indian university hospital.

Wilms tumor is one of the most common solid malignancies of childhood. The long-term result of the surgical treatment of this tumor with adjuvant chemotherapy and radiation has been reported from many western centers. However, there is paucity of literature on the long-term outcome of treatment for this tumor from the developing world. We planned a prospective study that started in 1999 to evaluate the 5-year tumor-free survival of Wilms tumor treated on a fixed protocol from a university hospital in India.
All consecutive children with Wilms tumor who were seen by any of the 3 investigators (2 pediatric oncologists, 1 pediatric surgeon) between 1999 and 2003 at the Advanced Pediatric Centre were included in the study. Each patient was entered into a database. Their demographic profile and events during the treatment and follow-up were recorded. This was later analyzed.
Seventy-five percent 5-year tumor-free survival has been achieved within the limitations of treatment in the developing world. The morbidity during therapy was 10% and the mortality 5%. This was based on the treatment of this common childhood malignancy at Chandigarh on a modified International Society of Pediatric Oncology protocol.
AuthorsAmita Trehan, Sujit K Chowdhary, Ram K Marwaha
JournalJournal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 34 Issue 1 Pg. 57-62 (Jan 2012) ISSN: 1536-3678 [Electronic] United States
PMID21423048 (Publication Type: Journal Article)
  • Biopsy, Fine-Needle
  • Child
  • Child, Preschool
  • Clinical Protocols
  • Combined Modality Therapy
  • Disease-Free Survival
  • Female
  • Hospitals, University
  • Humans
  • Kidney Neoplasms (mortality, pathology, therapy)
  • Male
  • Neoplasm Staging
  • Prospective Studies
  • Survival Rate
  • Wilms Tumor (mortality, pathology, therapy)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: