C1q nephropathy presenting as acute renal failure.

Abstract

We describe a 42-year-old male patient who presented with high grade fever associated with acute renal failure requiring hemodialysis. Renal biopsy revealed that he had focal proliferative glomerulonephritis on light microscopy, dominant mesangial deposition of C1q by immunofluorescent staining, and electron dense deposits on electron microscopy, with no evidence of systemic lupus erythematosus, compatible with the diagnosis of C1q nephropathy. Intensive treatment with a combination of methyl prednisolone pulse therapy and oral prednisolone was successful in achieving complete remission and disappearance of proteinuria in our patient.

• Authors: Pavan Malleshappa, Ravi Ranganath, Anup P Chaudhari, Ashwinikumar Ayiangar, Suratkal Lohitaksha
• Journal: Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia (Saudi J Kidney Dis Transpl) Vol. 22 Issue 2 Pg. 324-6 (Mar 2011) ISSN: 1319-2442 [Print] Saudi Arabia
• PMID: 21422635 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunosuppressive Agents
• Complement C1q
• Prednisolone
• Methylprednisolone

Topics

• Acute Kidney Injury (immunology, pathology, therapy)
• Administration, Oral
• Adult
• Biopsy
• Complement C1q (immunology)
• Drug Therapy, Combination
• Fever (immunology)
• Fluorescent Antibody Technique
• Glomerulonephritis (immunology, pathology, therapy)
• Humans
• Immunosuppressive Agents (administration & dosage)
• Kidney (immunology, ultrastructure)
• Male
• Methylprednisolone (administration & dosage)
• Microscopy, Electron
• Prednisolone (administration & dosage)
• Proteinuria (immunology)
• Pulse Therapy, Drug
• Renal Dialysis
• Treatment Outcome