The effect of triethanolamine application on anthralin-induced inflammation and therapeutic effect in psoriasis.

Abstract

Twenty patients with chronic plaque psoriasis were treated with short-contact anthralin followed by 10% triethanolamine application to one side of the body and aqueous cream to the other. Anthralin-induced inflammation was inhibited on the triethanolamine-treated side whereas anthralin therapy had to be temporarily stopped in 18 patients on the aqueous cream side because of anthralin-induced inflammation. Therapeutic response was not different in the two sides. This study shows that anthralin-induced inflammation and its therapeutic effect can be dissociated.

• Authors: B Ramsay, C M Lawrence, J M Bruce, S Shuster
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 23 Issue 1 Pg. 73-6 (Jul 1990) ISSN: 0190-9622 [Print] United States
• PMID: 2142172 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Ethanolamines
• triethanolamine
• Anthralin

Topics

• Adolescent
• Adult
• Aged
• Anthralin (administration & dosage, adverse effects)
• Double-Blind Method
• Drug Eruptions (drug therapy, etiology)
• Ethanolamines (therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Photochemotherapy
• Psoriasis (drug therapy, pathology)
• Recurrence
• Skin Pigmentation (drug effects)
• Time Factors