Malignant peripheral nerve sheath tumor arising from the greater omentum: case report.

Abstract

Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft tissue tumors that arise from a peripheral nerve or exhibit nerve sheath differentiation. Most of these tumors arise on the trunk, extremities, or head and neck regions; they are very rarely located in the abdominal cavity. The patient was a 71-year-old man who was referred to our hospital for a mass and pain in the right lower abdomen. Abdominal computed tomography revealed a large (9 × 9 cm), well-circumscribed, lobulated, heterogeneously enhanced mass in the pelvis. Exploratory laparotomy revealed a large mass in the greater omentum, and the tumor was completely excised. Histopathological analysis revealed that the tumor was composed of spindle cells with high mitotic activity. On staining the tumor, positive results were obtained for S-100 but negative results were obtained for c-kit, cluster of differentiation (CD)34, α-smooth muscle actin, and desmin. These findings strongly supported a diagnosis of MPNST primarily arising from the greater omentum. To the best of our knowledge, this is the first reported case of an MPNST arising from the greater omentum. In this report, we have described the case of a patient with an MPNST arising from the greater omentum and have discussed the clinical characteristics and management of MPNSTs.

• Authors: Masashi Miguchi, Yuji Takakura, Hiroyuki Egi, Takao Hinoi, Tomohiro Adachi, Yasuo Kawaguchi, Manabu Shinomura, Masakazu Tokunaga, Masazumi Okajima, Hideki Ohdan
• Journal: World journal of surgical oncology (World J Surg Oncol) Vol. 9 Pg. 33 (Mar 21 2011) ISSN: 1477-7819 [Electronic] England
• PMID: 21418642 (Publication Type: Case Reports, Journal Article)

Chemical References

• S100 Proteins

Topics

• Aged
• Humans
• Male
• Nerve Sheath Neoplasms (chemistry, pathology)
• Omentum (pathology)
• Peritoneal Neoplasms (pathology)
• S100 Proteins (analysis)