The association between cyclooxygenase-2 (COX-2/PTGS2) gene polymorphism and osteoarthritis.

Abstract

OBJECTIVES:

This study aims to investigate the relationship between the risk for the development of osteoarthritis and Cyclooxygenase-2 (COX 2) -765G>C gene polymorphism.

PATIENTS AND METHODS:

We included a total of 100 osteoarthritis patients (18 males, 82 females; mean age 60.4±8.4 years; range 41 to 81 years) who were treated in the Physical Therapy Clinic and 100 healthy subjects without a history of arthritis (40 males, 60 females; mean age 30.9±7.5 years; range 16 to 48 years) in our study between September 2006 and May 2008. The frequency of -765G>C gene polymorphism in the COX-2 promoter region was investigated in the osteoarthritis patients and the control group without a history of arthritis using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The data were analysed with chi-square and logistic regression analysis.

RESULTS:

The frequencies of -765G>C polymorphism for GG, GC and CC genotypes were found to be 54%, 35%, and 11% in the control group and 48%, 34% and 18% in the osteoarthritis group, respectively.

CONCLUSION:

Based on the data obtained, it can be stated that there is no significant relation between COX-2 -765G>C polymorphism and osteoarthritis disease. Furthermore, this study presents the first results of COX-2 promoter variant in Turkish patients with osteoarthritis.

• Authors: Volkan G Güler, Serap Yalın, Mehmet Berköz, Ozlem Bölgen Cimen, Erdinç Yalın, Pelin Eroğlu, Arzu Kanık
• Journal: Eklem hastaliklari ve cerrahisi = Joint diseases & related surgery (Eklem Hastalik Cerrahisi) Vol. 22 Issue 1 Pg. 22-7 ( 2011) ISSN: 1309-0313 [Electronic] Turkey
• PMID: 21417982 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cyclooxygenase 2

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Case-Control Studies
• Cyclooxygenase 2 (genetics)
• Female
• Gene Expression Regulation, Enzymologic (physiology)
• Gene Frequency
• Genetic Predisposition to Disease (genetics)
• Genotype
• Humans
• Male
• Middle Aged
• Osteoarthritis (enzymology, genetics)
• Polymorphism, Single Nucleotide
• Promoter Regions, Genetic (genetics)
• Young Adult