[Studies on metabolism and disposition of sizofiran (SPG), an anti-tumor polysaccharide. II. Effects on hepatic drug-metabolizing enzyme system in rats].

Abstract

The effect of a single or multiple administration of sizofiran (SPG), an anti-tumor polysaccharide, on a hepatic drug-metabolizing enzyme system was studied in rats. When SPG was given intravenously at a single dose of 0.5 or 10 mg/kg, no alteration was observed in activities of aminopyrine (AP) N-demethylase and aniline hydroxylase, and in cytochrome P-450 (P-450) content in the livers of rats 48 h after dosing. However, only AP demethylase activity decreased by 34% after the administration of 200 mg/kg. Similarly, no change in the hepatic enzyme activities and P-450 content was observed for up to 180 d after a single dose of 10 mg/kg. Subcutaneous treatment of animals with either 10 or 40 mg/kg dose for 3 and 6 months resulted in no alteration in the enzyme activities and P-450 content. These results may indicate that the therapeutically effective dose of SPG has no effect on a hepatic drug-metabolizing enzyme system in rats.

• Authors: S Tanji, K Akima, M Yoshioka, K Nomura, M Horiba, T Aimoto
• Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan (Yakugaku Zasshi) Vol. 110 Issue 2 Pg. 159-62 (Feb 1990) ISSN: 0031-6903 [Print] Japan
• PMID: 2141074 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Glycosaminoglycans
• Sizofiran
• Cytochrome P-450 Enzyme System
• Aniline Hydroxylase
• Aminopyrine N-Demethylase

Topics

• Aminopyrine N-Demethylase (metabolism)
• Aniline Hydroxylase (metabolism)
• Animals
• Antineoplastic Agents
• Cytochrome P-450 Enzyme System (metabolism)
• Glycosaminoglycans (pharmacology)
• Injections, Intravenous
• Injections, Subcutaneous
• Liver (enzymology)
• Male
• Rats
• Rats, Inbred Strains
• Sizofiran (administration & dosage, pharmacology)