The effect of T cell subset depletion on autoimmune thyroiditis in the Buffalo strain rat.

Abstract

The aim of these experiments was to analyse the functional roles of phenotypically defined T cells from Buffalo strain rats with immunisation or neonatal thymectomy-induced autoimmune thyroiditis. Rats were depleted either of CD8-positive T cells by administration of the Ox8 monoclonal antibody or of activated T cells by administration of low-dose cyclosporin A (Cs A) with an anti-IL-2 receptor monoclonal antibody (ART-18), and the effects on subsequent disease assessed. Even though animals were not completely depleted of Ox8 cells, immunisation-induced thyroiditis was enhanced by Ox8 treatment, whereas thyroglobulin antibodies were reduced compared with controls. Subtherapeutic doses of either Cs A or ART-18 alone had little effect on thymectomy-induced thyroiditis, in contrast to Cs A and ART-18 in conjunction, which prevented disease developing. These results suggest important roles for CD8-positive and IL-2 receptor-bearing T cells in experimental autoimmune thyroiditis.

• Authors: S B Cohen, T Diamantstein, A P Weetman
• Journal: Immunology letters (Immunol Lett) Vol. 23 Issue 4 Pg. 263-8 (Feb 1990) ISSN: 0165-2478 [Print] Netherlands
• PMID: 2140814 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Cyclosporins
• Receptors, Interleukin-2

Topics

• Animals
• Antibodies, Monoclonal (immunology)
• Cyclosporins (pharmacology)
• Female
• Immunization
• Lymphocyte Depletion
• Male
• Phenotype
• Rats
• Rats, Inbred BUF (immunology)
• Rats, Inbred Strains (immunology)
• Receptors, Interleukin-2 (immunology)
• T-Lymphocytes (immunology)
• T-Lymphocytes, Regulatory (immunology)
• Thymectomy (adverse effects)
• Thyroiditis, Autoimmune (immunology)