Evaluation of genetic susceptibility loci for chronic hepatitis B in Chinese: two independent case-control studies.

Abstract

BACKGROUND:

A recent genome-wide scan has identified two genetic variants in the HLA-DP region strongly associated with hepatitis B infection in Japanese. This study evaluates the effects of these risk variants in Chinese, where the HBV infection is the most popular in the world.

METHODS AND FINDINGS:

We have assessed the relationship between these two single nucleotide polymorphisms (rs3077 and rs9277535) and chronic hepatitis B infection in two independent case-control studies. The first population in Chinese Han included 736 patients and 782 spontaneously recovered controls. The second set was established in Chinese Zhuang minority of 177 patients and 208 controls. Both A alleles of rs3077 and rs9277535 significantly deceased the risk to CHB in Chinese Han (OR = 0.540, 95%CI: 0.464-0.628, P = 4.068×10(-16) and OR = 0.696, 95%CI: 0.601-0.806, P = 1.062×10(-6), respectively). Conceivably, rs9277535 was found to be associated with decreased risk of the disease in Chinese Zhuang, with an OR of 0.606 (95%CI, 0.441-0.833, P = 0.002).

CONCLUSION:

Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population. These findings might provide clues to develop screening and surveillance strategies.

• Authors: Li Wang, Xiao-Pan Wu, Wei Zhang, Da-Hai Zhu, Ying Wang, Yan-Ping Li, Yao Tian, Rong-Cheng Li, Zhuo Li, Xinlin Zhu, Jun-Hong Li, Jun Cai, Li Liu, Xiao-Ping Miao, Ying Liu, Hui Li
• Journal: PloS one (PLoS One) Vol. 6 Issue 3 Pg. e17608 (Mar 08 2011) ISSN: 1932-6203 [Electronic] United States
• PMID: 21408128 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adult
• Asian People (genetics)
• Case-Control Studies
• China
• Female
• Genetic Loci (genetics)
• Genetic Predisposition to Disease
• Haplotypes (genetics)
• Hepatitis B virus (physiology)
• Hepatitis B, Chronic (genetics, virology)
• Humans
• Male
• Polymorphism, Single Nucleotide (genetics)
• Treatment Outcome