Pregabalin in zolpidem dependence and withdrawal.

Several recent reports attest to zolpidem's strong potential for abuse, dependence, and severe withdrawal symptoms upon its discontinuation. We report, for the first time, on 1 case of heavy zolpidem abuse and dependence with severe withdrawal symptoms twice treated safely and successfully with pregabalin, a newer antiepileptic agent devoid of known strong potential for abuse and dependence.
AuthorsPanagiotis Oulis, George Nakkas, Vasilios G Masdrakis
JournalClinical neuropharmacology (Clin Neuropharmacol) 2011 Mar-Apr Vol. 34 Issue 2 Pg. 90-1 ISSN: 1537-162X [Electronic] United States
PMID21407000 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Anticonvulsants
  • Hypnotics and Sedatives
  • Pyridines
  • Pregabalin
  • gamma-Aminobutyric Acid
  • zolpidem
  • Anticonvulsants (therapeutic use)
  • Dysthymic Disorder (drug therapy)
  • Female
  • Humans
  • Hypnotics and Sedatives (adverse effects)
  • Middle Aged
  • Pregabalin
  • Pyridines (adverse effects)
  • Substance Withdrawal Syndrome (drug therapy, etiology)
  • gamma-Aminobutyric Acid (analogs & derivatives, therapeutic use)

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