Abstract | BACKGROUND AND OBJECTIVES: DESIGN AND SETTING: Open, prospective study of women admitted to university gynecology clinic. PATIENTS AND METHODS: The study included 26 patients with untreated hypothyroidism who had polycystic (n=10) or normal-appearing (n=16) ovaries and 20 euthyroidic controls. Basal serum total testosterone, free testosterone, androstenedione, dehydroepiandosterone- sulfate, prolactin, estradiol, luteinizing hormone, follicle-stimulating hormone, free T3, free T4 and thyroid-stimulating horone, together with ovarian volumes, were determined and repeated after euthyroidism was achieved. RESULTS: Ovarian volumes of patients with hypothyroidism were significantly greater compared with controls, and their magnitudes diminished significantly during thyroid hormone replacement therapy. Hypothyroidic patients with polycystic ovaries had significantly higher serum free testosterone and dehydroepiandosterone- sulfate, but lower androstenodione levels compared with those who had normal-appearing ovaries. Serum total testosterone concentrations were significantly higher in hypothyroidic patients without polycystic ovaries, and thyroid hormone replacement therapy achieved a significant reduction in total as well as free testosterone. CONCLUSION:
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Authors | Iptisam Ipek Muderris, Abdullah Boztosun, Gokalp Oner, Fahri Bayram |
Journal | Annals of Saudi medicine
(Ann Saudi Med)
2011 Mar-Apr
Vol. 31
Issue 2
Pg. 145-51
ISSN: 0975-4466 [Electronic] Saudi Arabia |
PMID | 21403408
(Publication Type: Journal Article)
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Chemical References |
- Androgens
- Hormones
- Thyroxine
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Topics |
- Adult
- Androgens
(blood)
- Case-Control Studies
- Female
- Hormones
(blood)
- Humans
- Hypothyroidism
(complications, drug therapy)
- Organ Size
(drug effects)
- Ovary
(drug effects, pathology)
- Polycystic Ovary Syndrome
(drug therapy, etiology)
- Prospective Studies
- Severity of Illness Index
- Thyroxine
(therapeutic use)
- Young Adult
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