This double-blind, parallel group multicentre study in 85 hospital out-patients with mild to moderate
acne evaluated the efficacy of 2.2 mg/ml topical
tetracycline or placebo applied twice daily for 16 weeks together with an initial course of oral
tetracycline, at doses of 1000 mg/day during weeks 1-4 and 500 mg/day during weeks 5-8.
Acne severity improved significantly (P less than 0.01) with both treatments after 8 and 16 weeks. After 4 weeks, 78% of patients using topical
tetracycline showed reduced
acne severity compared with 50% using placebo and, by week 16, improvements were 94% and 57%, respectively (P = 0.035). Global evaluations of patients and of investigators showed most improvement to occur within the first 8 weeks of treatment. Tingling and stinging were the most frequently reported adverse effects, occurring in similar frequencies in both treatment groups. Skin discoloration was more frequent in patients given topical
tetracycline. Overall, 90% of patients rated topical
tetracycline as 'cosmetically acceptable'. In conclusion, topical
tetracycline is useful in treatment of mild to moderate
acne when given with an initial course of oral
tetracycline and may enhance efficacy without unacceptable side-effects.