Activity of carbapenems combined with clavulanate against murine tuberculosis.

Abstract

Although beta-lactam antibiotics are not considered as antituberculous drugs, it has been recently shown that the combination of carbapenems and clavulanate is bactericidal in vitro. We evaluated in a murine model of tuberculosis the activity of carbapenems alone and combined with clavulanate against Mycobacterium tuberculosis. Swiss mice infected intravenously with 3 x 10⁵ M. tuberculosis H37Rv were treated for 4 weeks with clavulanate alone or imipenem, meropenem, and ertapenem alone or combined with clavulanate, whereas a positive control group was treated with isoniazid, and a negative control group was held without treatment. The combination of imipenem or meropenem plus clavulanate significantly improved survival. Among groups of mice with 100% survival, only isoniazid reduced lung CFU counts; the carbapenem-clavulanate combinations did not prevent bacterial growth. Although less active than isoniazid, the combinations of imipenem or meropenem plus clavulanate improved the survival of mice infected with M. tuberculosis and should be further evaluated.

• Authors: Nicolas Veziris, Chantal Truffot, Jean-Luc Mainardi, Vincent Jarlier
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 55 Issue 6 Pg. 2597-600 (Jun 2011) ISSN: 1098-6596 [Electronic] United States
• PMID: 21402832 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Carbapenems
• Clavulanic Acid

Topics

• Animals
• Anti-Bacterial Agents (administration & dosage)
• Bacterial Load
• Carbapenems (administration & dosage)
• Clavulanic Acid (administration & dosage)
• Drug Therapy, Combination
• Female
• Lung (drug effects, pathology)
• Mice
• Microbial Sensitivity Tests
• Spleen (drug effects, pathology)
• Tuberculosis (drug therapy, microbiology, pathology)