Abstract | OBJECTIVE: METHODS: The diagnostic value of the ALBIA assay was determined by comparing serum levels of anti-SRP autoantibodies in 31 anti-SRP immunodot-positive patients to those in 190 healthy blood donors and 199 control patients with different inflammatory/autoimmune conditions or polyclonal hypergammaglobulinemia. Among the 31 anti-SRP-positive patients, serum samples from 8 patients were monitored over time for levels of anti-SRP autoantibodies and levels of CK (determined at least 3 times, consecutively, over a mean followup period of 783 days). The relationship between levels of anti-SRP autoantibodies and levels of CK was tested using a linear mixed model. RESULTS: The assay yielded positive results for anti-SRP in all anti-SRP immunodot-positive serum samples tested, while all control sera tested negative. The 8 anti-SRP-positive patients who were followed up longitudinally were found to have normalized CK levels and improved muscle strength. There was a striking correlation between the degree of myolysis, as measured by CK levels, in patients receiving therapy and the anti-SRP54 autoantibody levels in these same patients (P = 0.002). CONCLUSION:
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Authors | Olivier Benveniste, Laurent Drouot, Fabienne Jouen, Jean-Luc Charuel, Coralie Bloch-Queyrat, Anthony Behin, Zahir Amoura, Isabelle Marie, Marguerite Guiguet, Bruno Eymard, Danièle Gilbert, François Tron, Serge Herson, Lucile Musset, Olivier Boyer |
Journal | Arthritis and rheumatism
(Arthritis Rheum)
Vol. 63
Issue 7
Pg. 1961-71
(Jul 2011)
ISSN: 1529-0131 [Electronic] United States |
PMID | 21400483
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 by the American College of Rheumatology. |
Chemical References |
- Autoantibodies
- Signal Recognition Particle
- Creatine Kinase
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Topics |
- Adult
- Aged
- Autoantibodies
(immunology)
- Blotting, Western
- Creatine Kinase
(immunology, metabolism)
- Female
- Humans
- Immunoassay
- Male
- Middle Aged
- Muscle, Skeletal
(immunology, pathology)
- Myositis
(immunology, pathology)
- Signal Recognition Particle
(immunology)
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