Antiobesity activities of indole-3-carbinol in high-fat-diet-induced obese mice.

This study investigated the effects of indole-3-carbinol (I3C), a cruciferous vegetable derivative, on obesity and its associated factors in high-fat-diet-induced obese (DIO) mice.
Eighteen male C57BL/6 mice were randomly assigned to one of three groups: basal, high fat (HF), and HF + 5 mg/kg of I3C intraperitoneally (HFI). After 12 wk of treatment, obesity-associated factors, including body weight, organ weight, serum concentrations of glucose, triacylglycerol, insulin, and adipokines, and macrophage accumulation and lipid metabolism-associated factors in epididymal adipose tissue were measured.
Body weight and epididymal adipose tissue weight were greater (P < 0.01), and adipocytes were larger in the HF group than in the basal and HFI groups. Compared with the HF group, the HFI group had improved glucose tolerance, a higher serum adiponectin concentration, lower serum glucose, triacylglycerol, insulin, and leptin concentrations, and less F4/80 expression in epididymal adipose tissue (P < 0.001). Furthermore, I3C treatment decreased acetyl coenzyme A carboxylase mRNA expression (P < 0.05) and increased peroxisome proliferator-activated receptor-γ protein expression (P < 0.05) in epididymal adipose tissue of DIO mice.
The I3C treatment decreased body weight and fat accumulation and infiltrated macrophages in epididymal adipose tissue of DIO mice, and these reductions were associated with improved glucose tolerance and with modulated expression of adipokines and lipogenic-associated gene products, including acetyl coenzyme A carboxylase and peroxisome proliferator-activated receptor-γ.
AuthorsHsiao-Pei Chang, Mei-Lin Wang, Ming-Hsing Chan, Yen-Shuo Chiu, Yue-Hwa Chen
JournalNutrition (Burbank, Los Angeles County, Calif.) (Nutrition) Vol. 27 Issue 4 Pg. 463-70 (Apr 2011) ISSN: 1873-1244 [Electronic] United States
PMID21392705 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2011 Elsevier Inc. All rights reserved.
Chemical References
  • Adiponectin
  • Anti-Obesity Agents
  • Blood Glucose
  • Dietary Fats
  • Indoles
  • Insulin
  • Leptin
  • PPAR gamma
  • Plant Extracts
  • RNA, Messenger
  • Triglycerides
  • indole-3-carbinol
  • Acetyl-CoA Carboxylase
  • Acetyl-CoA Carboxylase (genetics, metabolism)
  • Adiponectin (blood)
  • Adipose Tissue (cytology, drug effects, metabolism)
  • Animals
  • Anti-Obesity Agents (pharmacology, therapeutic use)
  • Blood Glucose (metabolism)
  • Body Weight (drug effects)
  • Brassicaceae (chemistry)
  • Dietary Fats (adverse effects)
  • Glucose Intolerance (drug therapy)
  • Indoles (pharmacology, therapeutic use)
  • Insulin (blood)
  • Leptin (blood)
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Obesity (blood, drug therapy, etiology)
  • Organ Size (drug effects)
  • PPAR gamma (metabolism)
  • Phytotherapy
  • Plant Extracts (pharmacology, therapeutic use)
  • RNA, Messenger (metabolism)
  • Triglycerides (blood)

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