Abstract |
One hundred and forty-three patients with partial epilepsy, aged 16-73 years, were treated with levetiracetam ( keppra) during 3 years. Group 1 included 71 patients who received the drug as the first monotherapy, group 2 consisted of 72 patients who received levetiracetam as the second or the third monotherapy due to the insufficient efficacy/poor tolerability of the initial therapy with AED. Percent of retention of patients on the drug is an integral index of the total efficacy of treatment (remission or >50% decrease of seizure frequency) minus the percent of drug withdrawal due to different reasons for a certain period. In group1, the percent of retention was 90,1% for the first year, 87,3% for the second year and 83,1% for the third year; in group 2-75% for the first year, 70,8% for the second year and 69,4% - for the third year. The drug was well-tolerated. The drug withdrawals due to side effects was 5,6% in group 1 and 8,2% in group 2. The results of the study suggest high efficacy of levetiracetam in treatment of partial epilepsy.
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Authors | P N Vlasov, V A Karlov, E G Komel'kova |
Journal | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
(Zh Nevrol Psikhiatr Im S S Korsakova)
Vol. 110
Issue 11 Pt 2
Pg. 15-20
( 2010)
ISSN: 1997-7298 [Print] Russia (Federation) |
PMID | 21389934
(Publication Type: Controlled Clinical Trial, Journal Article)
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Chemical References |
- Anticonvulsants
- Levetiracetam
- Piracetam
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Topics |
- Adolescent
- Adult
- Aged
- Anticonvulsants
(therapeutic use)
- Epilepsies, Partial
(drug therapy, physiopathology)
- Humans
- Levetiracetam
- Middle Aged
- Piracetam
(analogs & derivatives, therapeutic use)
- Treatment Outcome
- Withholding Treatment
- Young Adult
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