Soy isoflavone equol perpetuates dextran sulfate sodium-induced acute colitis in mice.

Abstract

The effects of the soy isoflavones, genistein, daidzein and equol, on experimental colitis were examined. Equol severely perpetrated dextran sulfate sodium (DSS)-induced colitis as evaluated by the weight loss. Production of the anti-inflammatory cytokine, IL-10, from T cells was decreased in the equol-treated mice. The results show that the soy isoflavone, equol, played an important role in the inflammatory response in the gastrointestinal tract.

• Authors: Tohru Sakai, Sakina Furoku, Mariko Nakamoto, Emi Shuto, Toshio Hosaka, Yasuhiko Nishioka, Saburo Sone
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 75 Issue 3 Pg. 593-5 ( 2011) ISSN: 1347-6947 [Electronic] England
• PMID: 21389602 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• 4',7-dihydroxy-3,4-dihydroisoflavone
• Isoflavones
• Interleukin-10
• Equol
• daidzein
• Dextran Sulfate
• Genistein

Topics

• Animals
• Body Weight (drug effects)
• Colitis (chemically induced, immunology, physiopathology)
• Dextran Sulfate (adverse effects)
• Disease Models, Animal
• Equol
• Female
• Genistein (adverse effects, pharmacology)
• Interleukin-10 (biosynthesis)
• Isoflavones (adverse effects, pharmacology)
• Mice
• Mice, Inbred BALB C
• T-Lymphocytes (drug effects, immunology)