[A case of eosinophilic pneumonia which occurred after bone marrow transplantation for acute myeloid leukemia].

Abstract

A 37-year-old woman with acute myeloid leukemia received allogeneic bone marrow transplantation (BMT) after systemic chemotherapy and total body irradiation. Soon after BMT both cutaneous and gastrointestinal graft-versus-host disease (GVHD) developed, but she was successfully treated with corticosteroids and tacrolimus. Thereafter, about 6 months after BMT a dry cough developed, and chest computed tomography (CT) showed a consolidated shadow in the right lower lobe which was resistant to antibiotics, and we finally diagnosed eosinophilic pneumonia based on a bronchoalveolar lavage analysis of the eosinophilia. The eosinophilic pneumonia in this case might have been associated with GVHD, because cutaneous GVHD simultaneously recurred. We report the details of this case because only a few such reports of eosinophilic pneumonia associated with GVHD have been previously described, and such cases may increase with the growing use of transplantations.

• Authors: Kenjiro Furuta, Masato Taki, Hiroki Murase, Atsushi Nakagawa, Hideki Nishiyama, Masaharu Nohgawa
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 49 Issue 1 Pg. 20-4 (Jan 2011) ISSN: 1343-3490 [Print] Japan
• PMID: 21384677 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Adult
• Bone Marrow Transplantation
• Female
• Graft vs Host Disease (complications)
• Humans
• Leukemia, Myeloid, Acute (therapy)
• Postoperative Complications
• Pulmonary Eosinophilia (etiology)
• Transplantation, Homologous