Falls in persons with chemotherapy-induced peripheral neuropathy.

Abstract

PURPOSE:

The purpose of this study was to evaluate possible risk factors for falls in a group of patients with chemotherapy-induced peripheral neuropathy (CIPN).

METHODS:

This prospective, descriptive study included persons receiving paclitaxel, docetaxel, oxaliplatin, or cispatin who reported at least one symptom of CIPN. Each patient was invited to complete the Chemotherapy-Induced Peripheral Neuropathy Assessment Tool (CIPNAT) and a demographic data questionnaire. Data were analyzed using descriptive statistics and logistic regression.

RESULTS:

In this sample (n = 109), fallers (n = 21) had higher doses of chemotherapy(p = 0.045), more neuropathic symptoms (p = 0.016), higher scores on the symptom experience (p = 0.005) and interference items (=0.001) on the CIPNAT, more severe muscle weakness (p < 0.001) and loss of balance (p < 0.001), and higher interference with walking(p < 0.001) and driving (p = 0.022). Patients who received taxanes were more likely to have fallen than patients who received platinum-based chemotherapy (p = 0.022). No significant differences in age or disease stage between fallers and non-fallers were present. Severity of loss of balance and cycle number was independently associated with falling.

CONCLUSIONS:

This study demonstrates that the risk of falls increases with each cycle of chemotherapy and that patients receiving taxanes may be at greater risk of falls than patients receiving neurotoxic platinum-based drugs. Patients who report muscle weakness and loss of balance or say that their symptoms interfere with walking or driving may be at a higher risk of falls.

• Authors: Cindy Tofthagen, Janine Overcash, Kevin Kip
• Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (Support Care Cancer) Vol. 20 Issue 3 Pg. 583-9 (Mar 2012) ISSN: 1433-7339 [Electronic] Germany
• PMID: 21380613 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Organoplatinum Compounds
• Taxoids
• Oxaliplatin
• Docetaxel
• Paclitaxel

Topics

• Accidental Falls (statistics & numerical data)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Causality
• Comorbidity
• Docetaxel
• Female
• Humans
• Logistic Models
• Male
• Middle Aged
• Muscle Weakness (chemically induced, epidemiology)
• Neoplasm Staging
• Neoplasms (classification, drug therapy, pathology)
• Organoplatinum Compounds (administration & dosage)
• Oxaliplatin
• Paclitaxel (administration & dosage)
• Peripheral Nervous System Diseases (chemically induced, epidemiology)
• Population Surveillance
• Postural Balance
• Prospective Studies
• Risk Factors
• Sensation Disorders (chemically induced, epidemiology)
• Severity of Illness Index
• Surveys and Questionnaires
• Taxoids (administration & dosage)