Abstract |
As part of a large, multicenter trial, 82 patients with endometriosis were randomized to 6 months of treatment with either nafarelin or danazol. Among 73 patients who had subjective symptoms ( dysmenorrhea, dyspareunia, or pelvic pain) at baseline, 94% of patients treated with nafarelin and 91% of those treated with danazol had improvement. Resolution of physical findings also was observed in similar percentages of patients in each treatment group. Long-term studies are needed to determine whether these two agents are associated with different cure rates or times to recurrence of disease.
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Authors | R W Shaw |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 162
Issue 2
Pg. 574-6
(Feb 1990)
ISSN: 0002-9378 [Print] United States |
PMID | 2137972
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Nafarelin
- Gonadotropin-Releasing Hormone
- Danazol
|
Topics |
- Amenorrhea
(chemically induced)
- Clinical Trials as Topic
- Danazol
(therapeutic use)
- Endometriosis
(drug therapy)
- Female
- Gonadotropin-Releasing Hormone
(analogs & derivatives, therapeutic use)
- Humans
- Nafarelin
- Pain
(drug therapy, etiology)
|