Abstract | PURPOSE: METHODS:
Kynurenine (kyn)/trp serum ratio, as an indicator of IDO activity was analyzed in 271 carefully classified epilepsy patients, and 309 healthy adults. RESULTS: IDO activity was increased in patients with unclassified idiopathic generalized epilepsy ( IGE) (n=11; p=0.05), in juvenile myoclonic epilepsy (JME) (n=25; p=0.04) and in patients those with temporal lobe epilepsy but no hippocampal sclerosis (TLE-HS) (n=103; p=0.05) compared to the control subjects. In patients with idiopathic (but not cryptogenic or symptomatic) etiology of epilepsy, IDO activity was increased compared to the control subjects (p<0.05). Patients with extra-TLE or TLE+HS had IDO activity comparable to the control subjects. Patients who were one-month seizure-free prior to sampling had increased IDO activity compared to the control subjects (p=0.03). CONCLUSIONS: Increased IDO activity appeared to be associated with idiopathic generalized epilepsies such as unclassified IGE and JME, two of the most common types of primary generalized epilepsy. We also found a trend of increased IDO activity in patients with TLE-HS. Our results suggest that increased IDO activity may represent an adaptive metabolic phenomenon in epilepsy, which may also have a neuroprotective or anticonvulsive role by downregulating neuroinflammation in the brain.
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Authors | Suvi Liimatainen, Kai Lehtimäki, Annika Raitala, Maria Peltola, Simo S Oja, Jukka Peltola, Mikko A Hurme |
Journal | Epilepsy research
(Epilepsy Res)
Vol. 94
Issue 3
Pg. 206-12
(May 2011)
ISSN: 1872-6844 [Electronic] Netherlands |
PMID | 21377330
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Elsevier B.V. All rights reserved. |
Chemical References |
- Indoleamine-Pyrrole 2,3,-Dioxygenase
- Serotonin
- Kynurenine
- Tryptophan
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Topics |
- Adult
- Epilepsy, Generalized
(blood)
- Female
- Humans
- Indoleamine-Pyrrole 2,3,-Dioxygenase
(blood)
- Kynurenine
(blood)
- Male
- Middle Aged
- Serotonin
(blood)
- Tryptophan
(blood)
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