Clinical features and treatment in patients with acute 2,4-dinitrophenol poisoning.

Abstract

OBJECTIVE:

To report clinical features and treatment of 16 cases of acute 2,4-dinitrophenol poisoning.

METHODS:

A total of 16 patients suffering from acute poisoning due to non-oral exposure to 2,4-dinitrophenol were sent to our hospital. Two died within 3 h after admission, while the other 14 responded to supportive treatment and hemoperfusion. Clinical features and treatment of the patients were retrospectively analyzed and presented.

RESULTS:

Fourteen patients recovered and were discharged after four to six weeks of treatment. No obvious poisoning sequelae were found in the three-month follow-up.

CONCLUSIONS:

Non-oral exposure to 2,4-dinitrophenol is toxic. Hemoperfusion and glucocorticoid treatments may be efficient measures to prevent mortality, but this requires further study.

• Authors: Yuan-qiang Lu, Jiu-kun Jiang, Wei-dong Huang
• Journal: Journal of Zhejiang University. Science. B (J Zhejiang Univ Sci B) Vol. 12 Issue 3 Pg. 189-92 (Mar 2011) ISSN: 1862-1783 [Electronic] China
• PMID: 21370503 (Publication Type: Journal Article)

Chemical References

• Glucocorticoids
• 2,4-Dinitrophenol

Topics

• 2,4-Dinitrophenol (poisoning)
• Adolescent
• Adult
• Child
• Female
• Glucocorticoids (therapeutic use)
• Humans
• Male
• Middle Aged
• Occupational Exposure
• Perfusion
• Poisoning (mortality)
• Respiratory System (drug effects)
• Retrospective Studies
• Skin (drug effects)
• Time Factors
• Treatment Outcome