Monthly cyproterone acetate in the treatment of hirsute women: clinical and laboratory effects.

Abstract

Cyproterone acetate given as a single intramuscular dose of 300 mg monthly for 6 months resulted in significant reduction of hirsutism without appreciable side effects. This regimen resulted in decreased levels of luteinizing hormone (LH) and estradiol in the eight women studied. No significant changes were observed in total serum testosterone (T) levels, however, there was a reduction in sex hormone binding globulin (SHBG), resulting in lowered SHBG-bound T, and an increase in non-SHBG-T over this time. Serum androstanediol glucuronide levels decreased in three of four women, although not to normal levels.

• Authors: J A Marcondes, B L Wajchenberg, A C Abujamra, W W Luthold, E Samojlik, M A Kirschner
• Journal: Fertility and sterility (Fertil Steril) Vol. 53 Issue 1 Pg. 40-4 (Jan 1990) ISSN: 0015-0282 [Print] United States
• PMID: 2136835 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Albumins
• Androgen Antagonists
• Sex Hormone-Binding Globulin
• Testosterone
• Cyproterone Acetate
• Cyproterone

Topics

• Adolescent
• Adult
• Albumins (metabolism)
• Androgen Antagonists (therapeutic use)
• Cyproterone (analogs & derivatives, therapeutic use)
• Cyproterone Acetate
• Dose-Response Relationship, Drug
• Female
• Hirsutism (drug therapy, metabolism)
• Humans
• Sex Hormone-Binding Globulin (metabolism)
• Testosterone (blood)