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Artemisinin evaluation in Romanian Artemisia annua wild plants using a new HPLC/MS method.

Abstract
Artemisinin, a sesquiterpene lactone from Artemisia annua L., has received considerable attention in the last few decades as a potent antimalarial drug. Artemisinin has rather low toxicity; it is effective against drug-resistant Plasmodium species and against cerebral malaria. This study reports the development of a rapid and sensitive assay for the quantification of artemisinin in A. annua by reversed phase HPLC/MS. In the selected optimal experimental conditions, artemisinin exhibited a well-defined chromatographic peak with a retention time of 2 ± 0.2 min. The chromatographic signal shows a linear dependence with artemisinin concentration, enabling the use of this signal for artemisinin quantification according to the following regression equation: y = 2665.40x - 14697.61. The correlation coefficient (R(2)) was 0.9989. For every concentration within the range of the standard curve (0.1-2 µg mL(-1)), accuracy was between 95 and 104%. Artemisinin content in Romanian A. annua wild plants varies between 0.17 and 0.21% (dry weight basis).
AuthorsB Ivanescu, L Vlase, A Corciova, M I Lazar
JournalNatural product research (Nat Prod Res) Vol. 25 Issue 7 Pg. 716-22 (Apr 2011) ISSN: 1478-6427 [Electronic] England
PMID21360406 (Publication Type: Journal Article)
Chemical References
  • Antimalarials
  • Artemisinins
  • Plant Extracts
  • artemisinine
Topics
  • Antimalarials (analysis)
  • Artemisia annua (chemistry)
  • Artemisinins (analysis)
  • Chromatography, High Pressure Liquid (methods)
  • Plant Components, Aerial (chemistry)
  • Plant Extracts (chemistry)
  • Romania
  • Tandem Mass Spectrometry

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