Abstract | OBJECTIVE: METHODS AND RESULTS: CONCLUSION:
Apelin protects against cardiac fibrosis and vascular remodeling through direct regulation of PAI-1 gene expression. This protective effect is mediated through the synergistic inhibition of Ang II signaling and increased production of nitric oxide by apelin. Our data extend previous findings and provide new insight into the molecular mechanisms by which apelin elicits a cardioprotective effect.
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Authors | Khandaker Siddiquee, Jessica Hampton, Susan Khan, Dan Zadory, Linda Gleaves, Douglas E Vaughan, Layton H Smith |
Journal | Journal of hypertension
(J Hypertens)
Vol. 29
Issue 4
Pg. 724-31
(Apr 2011)
ISSN: 1473-5598 [Electronic] England |
PMID | 21358420
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- APLN protein, human
- Apelin
- Intercellular Signaling Peptides and Proteins
- Plasminogen Activator Inhibitor 1
- Angiotensin II
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Topics |
- Angiotensin II
(adverse effects, antagonists & inhibitors)
- Animals
- Apelin
- Cardiovascular Diseases
(etiology, prevention & control)
- Fibrosis
(prevention & control)
- Intercellular Signaling Peptides and Proteins
(physiology)
- Male
- Mice
- Plasminogen Activator Inhibitor 1
(biosynthesis)
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