Regulation of tyrosine phosphorylation in macrophage phagocytosis and chemotaxis.

Abstract

Macrophages display a large variety of surface receptors that are critical for their normal cellular functions in host defense, including finding sites of infection (chemotaxis) and removing foreign particles (phagocytosis). However, inappropriate regulation of these processes can lead to human diseases. Many of these receptors utilize tyrosine phosphorylation cascades to initiate and terminate signals leading to cell migration and clearance of infection. Actin remodeling dominates these processes and many regulators have been identified. This review focuses on how tyrosine kinases and phosphatases regulate actin dynamics leading to macrophage chemotaxis and phagocytosis.

• Authors: Haein Park, Dan Ishihara, Dianne Cox
• Journal: Archives of biochemistry and biophysics (Arch Biochem Biophys) Vol. 510 Issue 2 Pg. 101-11 (Jun 15 2011) ISSN: 1096-0384 [Electronic] United States
• PMID: 21356194 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)
• Copyright: Copyright © 2011 Elsevier Inc. All rights reserved.

Chemical References

• Tyrosine

Topics

• Animals
• Chemotaxis
• Humans
• Macrophages (cytology, enzymology, metabolism)
• Phagocytosis
• Phosphorylation
• Signal Transduction
• Tyrosine (metabolism)