[Protective effects of xuefu zhuyu decoction on myocardium ischemia reperfusion injury in rats].

Abstract

OBJECTIVE:

To investigate the protective effects of Xuefu Zhuyu decoction on myocardium ischemia reperfusion injury in rats.

METHOD:

36 SD rats were divided into 3 groups randomly, sham-operated group, model group, Xuefu Zhuyu decoction group. The model of MI/RI of the myocardium was reproduced by ligation of left descending artery for 30 min followed by releasing the ligation for 2 hours in rats. Serum contents of LDH-L, CK were measured, the levels of serum IL-1beta, IL-6 and IL-10 were measured and myocardial ultrastructure at the ischemia region was observed under the transmission electron microscope after myocardial reperfusion injury.

RESULT:

Compared with model group, IL-1beta, IL-6 and IL-10 levels were lower, myocardial ultrastructural changes were improved in Xuefu Zhuyu decoction group (P < 0.01), however, serum contents of LDH-L and CK no significant difference were found among the model group and Xuefu Zhuyu decoction group.

CONCLUSION:

Xuefu Zhuyu decoction can protect myocardium from MI/RI, the mechanism of action was related to inhibiting inflammatory reaction and reducing arrhythmia and the injury of the myocardial ultrastructure.

• Authors: Danli Tang, Zhaihua Liu, Huamin Zhang, Mingjie Sun, Yu Sui
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 35 Issue 22 Pg. 3077-9 (Nov 2010) ISSN: 1001-5302 [Print] China
• PMID: 21355287 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• Interleukin-6
• Protective Agents
• Xue-Fu-Zhu-Yu decoction
• Interleukin-10

Topics

• Animals
• Disease Models, Animal
• Drugs, Chinese Herbal (therapeutic use)
• Humans
• Interleukin-10 (immunology)
• Interleukin-6 (immunology)
• Male
• Myocardial Reperfusion Injury (drug therapy, immunology, prevention & control)
• Protective Agents (therapeutic use)
• Random Allocation
• Rats
• Rats, Sprague-Dawley