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[Protective effects of xuefu zhuyu decoction on myocardium ischemia reperfusion injury in rats].

AbstractOBJECTIVE:
To investigate the protective effects of Xuefu Zhuyu decoction on myocardium ischemia reperfusion injury in rats.
METHOD:
36 SD rats were divided into 3 groups randomly, sham-operated group, model group, Xuefu Zhuyu decoction group. The model of MI/RI of the myocardium was reproduced by ligation of left descending artery for 30 min followed by releasing the ligation for 2 hours in rats. Serum contents of LDH-L, CK were measured, the levels of serum IL-1beta, IL-6 and IL-10 were measured and myocardial ultrastructure at the ischemia region was observed under the transmission electron microscope after myocardial reperfusion injury.
RESULT:
Compared with model group, IL-1beta, IL-6 and IL-10 levels were lower, myocardial ultrastructural changes were improved in Xuefu Zhuyu decoction group (P < 0.01), however, serum contents of LDH-L and CK no significant difference were found among the model group and Xuefu Zhuyu decoction group.
CONCLUSION:
Xuefu Zhuyu decoction can protect myocardium from MI/RI, the mechanism of action was related to inhibiting inflammatory reaction and reducing arrhythmia and the injury of the myocardial ultrastructure.
AuthorsDanli Tang, Zhaihua Liu, Huamin Zhang, Mingjie Sun, Yu Sui
JournalZhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 35 Issue 22 Pg. 3077-9 (Nov 2010) ISSN: 1001-5302 [Print] China
PMID21355287 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Drugs, Chinese Herbal
  • Interleukin-6
  • Protective Agents
  • Xue-Fu-Zhu-Yu decoction
  • Interleukin-10
Topics
  • Animals
  • Disease Models, Animal
  • Drugs, Chinese Herbal (therapeutic use)
  • Humans
  • Interleukin-10 (immunology)
  • Interleukin-6 (immunology)
  • Male
  • Myocardial Reperfusion Injury (drug therapy, immunology, prevention & control)
  • Protective Agents (therapeutic use)
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley

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