Abstract |
A new fipronil-based spot-on formulation was evaluated against experimental flea infestations in cats in two studies. In both studies, eight cats served as negative controls (groups 1 and 4); on day 0, eight cats were treated with a 10% w/v fipronil-based spot-on solution (Effipro Spot-on, 0.5ml per cat, groups 2 and 5) and eight cats served as positive controls (Frontline Spot-on, 0.5ml per cat, groups 3 and 6). Each cat was infested on day - 1 with 50 fleas (study 1) and weekly (day 7-day 56) with 100 fleas (study 2). Geometric mean flea counts obtained 48h after the treatment or each re-infestation were reduced by 99.0 and 98.3% in groups 2 and 3, respectively, on day 2, compared to the negative control group. Cats were protected from re-infestations with an efficacy >99% for 58 days in group 5 and for 37 days in group 6.
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Authors | Marie-Christine Cadiergues, Stéphane G Bonneau, Josephus J Fourier |
Journal | Journal of feline medicine and surgery
(J Feline Med Surg)
Vol. 13
Issue 4
Pg. 304-8
(Apr 2011)
ISSN: 1532-2750 [Electronic] England |
PMID | 21354841
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 ISFM and AAFP. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Insecticides
- Pyrazoles
- fipronil
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Topics |
- Animals
- Cat Diseases
(drug therapy)
- Cats
- Ctenocephalides
(drug effects)
- Female
- Flea Infestations
(drug therapy, veterinary)
- Insecticides
(therapeutic use)
- Male
- Pyrazoles
(therapeutic use)
- Treatment Outcome
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