Abstract | BACKGROUND: METHODS: The hearts were excised from 16- and 80-week-old Lewis donor rats, stored in HTK, CEL, or saline for 6 hours and heterotopically transplanted into syngenic young Lewis recipients. Serum troponin I and creatine phosphokinase, graft infiltrating cells, graft apoptosis, graft proinflammatory messenger ribonucleic acid levels, and adenosine monophosphate-activated protein kinase phosphorylation were analyzed 3, 6, and 12 hours after reperfusion as markers of graft injury. Tissue adenosine triphosphate levels were measured after cold storage for 0, 6, 12, and 18 hours. RESULTS: CONCLUSIONS:
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Authors | Sungsoo Lee, Chien-Sheng Huang, Tomohiro Kawamura, Norihisa Shigemura, Timothy R Billiar, Atsunori Nakao, Yoshiya Toyoda |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 91
Issue 3
Pg. 755-63
(Mar 2011)
ISSN: 1552-6259 [Electronic] Netherlands |
PMID | 21352993
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Bretschneider cardioplegic solution
- Celsior
- Disaccharides
- Electrolytes
- Glutamates
- Organ Preservation Solutions
- Mannitol
- Histidine
- Procaine
- Potassium Chloride
- Glutathione
- Glucose
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Topics |
- Animals
- Cold Temperature
- Disaccharides
(pharmacology)
- Disease Models, Animal
- Electrolytes
(pharmacology)
- Glucose
(pharmacology)
- Glutamates
(pharmacology)
- Glutathione
(pharmacology)
- Heart
- Heart Transplantation
- Histidine
(pharmacology)
- Male
- Mannitol
(pharmacology)
- Organ Preservation
(methods)
- Organ Preservation Solutions
(pharmacology)
- Potassium Chloride
(pharmacology)
- Procaine
(pharmacology)
- Rats
- Rats, Inbred Lew
- Reperfusion Injury
(prevention & control)
- Tissue Donors
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