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[Impact of antiretroviral therapy on occurrences of macrocytosis in patients with HIV/AIDS in Maringá, State of Paraná].

AbstractINTRODUCTION:
AIDS is a disease caused by HIV that compromises the organism's immune system. The advent of highly active antiretroviral therapy (HAART) has promoted substantial improvement in the prognosis for this disease and in HIV/AIDS patients' quality of life. During prolonged treatment, certain hematological disorders are observed, such as anemia and macrocytosis, as well as deficiencies of micronutrient such as vitamin B12 and folic acid. The objective of this study was to correlate the presence of macrocytosis and anemia with HAART use or vitamin B12 and folic acid deficiencies.
METHODS:
110 HIV-positive patients were included, in three groups: HAART use with zidovudine (AZT) (group 1), HAART use without AZT (group 2) and no HAART (group 3).
RESULTS:
None of the patients in any of the three groups presented statistically significant differences relating to hemoglobin level (p = 0.584) or folic acid level (p = 0.956). Group 1 (G1) had a higher mean corpuscular volume (MCV) than G3 (p < 0.05), and group 2 (G2) had a higher volume than group 3 (G3) (p < 0.001). Vitamin B12 levels in G1 and G3 were smaller than those in G2 (p = 0.008).
CONCLUSIONS:
It was concluded that patients undergoing HAART treatment presented macrocytosis, even though this could not be correlated with the type of HAART or with vitamin B12 deficiency. However, folic acid deficiency was unrelated to either HAART or macrocytosis.
AuthorsOdete Correia Antunes de Oliveira, Ramon Antunes de Oliveira, Lenice do Rosário de Souza
JournalRevista da Sociedade Brasileira de Medicina Tropical (Rev Soc Bras Med Trop) 2011 Jan-Feb Vol. 44 Issue 1 Pg. 35-9 ISSN: 1678-9849 [Electronic] Brazil
Vernacular TitleImpacto do tratamento antirretroviral na ocorrência de macrocitose em pacientes com HIV/AIDS do município de Maringá, Estado do Paraná
PMID21340405 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Anti-HIV Agents
  • Zidovudine
Topics
  • Adult
  • Anemia, Macrocytic (chemically induced)
  • Anti-HIV Agents (adverse effects, therapeutic use)
  • Antiretroviral Therapy, Highly Active (adverse effects)
  • CD4 Lymphocyte Count
  • Female
  • Folic Acid Deficiency (chemically induced)
  • HIV Infections (diagnosis, drug therapy)
  • Humans
  • Male
  • Middle Aged
  • Retrospective Studies
  • Viral Load
  • Vitamin B 12 Deficiency (chemically induced)
  • Zidovudine (adverse effects, therapeutic use)

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