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Acute isolated ophthalmoplegia with anti-GQ1b antibodies.

Abstract
Ophthalmoplegia without ataxia, areflexia or both has been designated as atypical Miller Fisher syndrome (MFS) or acute ophthalmoplegia (AO). This entity, first reported by Chiba et al. is associated with anti-GQ1b IgG antibodies.We report a patient with isolated acute ophthalmoplegia with high titer of anti-GQ1b IgG antibody activity in the acute phase in whom treatment with intravenous immunoglobulin (IVIg) led to the clinical recovery and the decrease in antibody titer.
AuthorsAndrea Rigamonti, Giuseppe Lauria, Marco Longoni, Lorenzo Stanzani, Elio Agostoni
JournalNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (Neurol Sci) Vol. 32 Issue 4 Pg. 681-2 (Aug 2011) ISSN: 1590-3478 [Electronic] Italy
PMID21336874 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Gangliosides
  • Immunoglobulin G
  • Immunoglobulins, Intravenous
  • GQ1b ganglioside
Topics
  • Acute Disease
  • Adult
  • Blepharoptosis (etiology)
  • Diplopia (etiology)
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Gangliosides (immunology)
  • Humans
  • Immunoglobulin G (immunology)
  • Immunoglobulins, Intravenous (therapeutic use)
  • Miller Fisher Syndrome (immunology, therapy)
  • Neural Conduction (physiology)
  • Neurologic Examination

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