Abstract | BACKGROUND: We recently showed that mechanisms of protein turnover in skeletal muscle are unresponsive to amino acid (AA) infusion in severely burned pediatric patients at 6 months postinjury. In the current study, we evaluated whether oxandrolone treatment affects mechanisms of protein turnover in skeletal muscle and whole-body protein breakdown in pediatric burn patients 6 months postinjury. METHODS: At the time of admission, patients were randomized to control or oxandrolone treatments. The treatment regimens were continued until 6 months postinjury, at which time patients (n = 26) underwent study with a stable isotope tracer infusion to measure muscle and whole-body protein turnover. RESULTS:
Protein kinetics in leg muscle were expressed in nmol/min per 100 mL leg volume (mean ± SE). During AA infusion, rates of protein synthesis in leg muscle were increased (P < .05) in both groups (basal vs AA: control, 51 ± 8 vs 86 ± 21; oxandrolone, 56 ± 7 vs 96 ± 12). In the control group, there was also a simultaneous increase in breakdown (basal vs AA: 65 ± 10 vs 89 ± 25), which resulted in no change in the net balance of leg muscle protein (basal vs AA: -15 ± 4 vs -2 ± 10). In the oxandrolone group, protein breakdown did not change (basal vs AA: 80 ± 12 vs 77 ± 9), leading to increased net balance (basal vs AA: -24 ± 7 vs 19 ± 7; P < .05). Protein breakdown at the whole-body level was not different between the groups. CONCLUSION:
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Authors | Demidmaa Tuvdendorj, David L Chinkes, Xiao-Jun Zhang, Oscar E Suman, Asle Aarsland, Arny Ferrando, Gabriela A Kulp, Marc G Jeschke, Robert R Wolfe, David N Herndon |
Journal | Surgery
(Surgery)
Vol. 149
Issue 5
Pg. 645-53
(May 2011)
ISSN: 1532-7361 [Electronic] United States |
PMID | 21333314
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2011 Mosby, Inc. All rights reserved. |
Chemical References |
- Amino Acids
- Anabolic Agents
- Muscle Proteins
- Oxandrolone
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Topics |
- Amino Acids
(metabolism)
- Anabolic Agents
(pharmacology, therapeutic use)
- Burns
(drug therapy, metabolism)
- Child
- Follow-Up Studies
- Humans
- Leg
- Longitudinal Studies
- Muscle Proteins
(metabolism)
- Muscle, Skeletal
(metabolism)
- Oxandrolone
(pharmacology, therapeutic use)
- Treatment Outcome
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