HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Human cadaveric dermal matrix for management of challenging surgical defects on the scalp.

AbstractBACKGROUND:
Biologic scaffolds have shown promise in patients unable to tolerate prolonged surgical closure or extensive wound care, but there has been little research in the field of Mohs micrographic surgery (MMS) on human cadaveric dermis in this capacity.
OBJECTIVE:
To evaluate the utility of human cadaveric dermis as a means of decreasing operative time, minimizing postoperative wound care, and improving aesthetic outcomes in selected patients with deep surgical defects, including those with exposed bone.
METHODS:
Fourteen patients (8 men, 6 women) with deep postoperative defects after MMS were treated with a cadaveric dermal allograft as part or all of their postoperative wound management.
RESULTS:
Allograft placement was well tolerated, with high satisfaction levels relating to minimal postoperative wound care and aesthetic outcome. Significantly shorter operative times were noted in all patients than with primary closure or grafting.
CONCLUSION:
In patients with significant comorbidities, inability to tolerate extended surgical repairs, or inability to perform extensive wound care, human cadaveric dermal allografts can decrease operative time and minimize wound care complexity while providing an excellent aesthetic outcome in many cases. Shorter healing times than expected were also noted in a number of patients. The authors have indicated no significant interest with commercial supporters.
AuthorsWilliam G Stebbins, C William Hanke, Jeffrey Petersen
JournalDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] (Dermatol Surg) Vol. 37 Issue 3 Pg. 301-10 (Mar 2011) ISSN: 1524-4725 [Electronic] United States
PMID21324041 (Publication Type: Journal Article)
Copyright© 2011 by the American Society for Dermatologic Surgery, Inc.
Topics
  • Aged
  • Aged, 80 and over
  • Cadaver
  • Dermis (transplantation)
  • Female
  • Humans
  • Male
  • Mohs Surgery
  • Patient Satisfaction
  • Postoperative Care
  • Plastic Surgery Procedures (methods)
  • Scalp (surgery)
  • Time Factors
  • Transplantation, Homologous
  • Treatment Outcome
  • Wound Healing

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: