A premenopausal woman with virilization secondary to an ovarian Leydig cell tumor.

Abstract

BACKGROUND:

A 33-year-old woman presented to an endocrinology clinic with a 5-year history of secondary amenorrhea. 2 years before presentation, she had noticed progressively worsening signs of virilization.

INVESTIGATIONS:

Measurement of levels of serum free and total testosterone, androstenedione, dehydroepiandrosterone sulfate and gonadotropins; transvaginal ultrasonography, abdominal and pelvic MRI and (18)F-fluorodeoxyglucose PET imaging.

DIAGNOSIS:

Virilization secondary to an ovarian Leydig cell tumor.

MANAGEMENT:

The patient underwent a left salpingo-oophorectomy that confirmed the diagnosis of a unilateral Leydig cell tumor. Complete normalization of androgens and gonadotropin levels was achieved after surgery.

• Authors: André M Faria, Ricardo V Perez, José A M Marcondes, Daniel S Freire, Roberto Blasbalg, José Soares Jr, Kleber Simões, Sylvia A Y Hayashida, Maria A A Pereira
• Journal: Nature reviews. Endocrinology (Nat Rev Endocrinol) Vol. 7 Issue 4 Pg. 240-5 (Apr 2011) ISSN: 1759-5037 [Electronic] England
• PMID: 21321567 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2011 Macmillan Publishers Limited. All rights reserved

Topics

• Adult
• Female
• Humans
• Leydig Cell Tumor (blood, diagnosis, surgery)
• Ovarian Neoplasms (blood, diagnosis, surgery)
• Premenopause (blood)
• Virilism (blood, diagnosis, surgery)