[Colonic malacoplakia treated with sulfamethizole and trimethoprim].

Abstract

We report a case of colonic malacoplakia in a 78-year-old woman, developed following short-term treatment with prednisolone. Clinically, the patient presented with diarrhoea (up to ten times a day) and malaise. Laboratory tests revealed severe anaemia and elevated inflammatory parameters. Colonoscopy showed macroscopic yellowish nodular changes throughout the colon. Biopsies were diagnostic for malacoplakia and exhibited moderate growth of Escherichia faecium and ciprofloxacin-resistant Escherichia coli. The condition resolved during three months of antibiotic treatment with sulfamethizole and trimethoprim.

• Authors: Mikkel Christensen, Svend Knuhtsen, Elisabeth Knudsen
• Journal: Ugeskrift for laeger (Ugeskr Laeger) Vol. 173 Issue 7 Pg. 509-10 (Feb 14 2011) ISSN: 1603-6824 [Electronic] Denmark
• Vernacular Title: Malokoplaki i colon behandlet med sulfamethizol og trimetoprim.
• PMID: 21320418 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Anti-Infective Agents
• Sulfamethizole
• Trimethoprim

Topics

• Aged
• Anti-Infective Agents (therapeutic use)
• Colon, Transverse (microbiology, pathology)
• Colonic Diseases (drug therapy, microbiology, pathology)
• Colonoscopy
• Drug Therapy, Combination
• Female
• Humans
• Malacoplakia (drug therapy, microbiology, pathology)
• Sulfamethizole (therapeutic use)
• Treatment Outcome
• Trimethoprim (therapeutic use)