Different vitamin D substrate-product relationship after oral vitamin D supplementation in familial benign hypercalcemia, primary hyperparathyroidism, and healthy controls.

Abstract

CONTEXT:

In healthy subjects and in patients with primary hyperparathyroidism (PH), the administration of a low dose of 25(OH)D (25 μg/day) increases the serum levels of both 25(OH)D and 1,25(OH)(2)D. It is unknown whether this relationship is present in patients affected by familial benign hypocalciuric hypercalcemia (FBH).

OBJECTIVE:

To evaluate the different vitamin D substrate-product relationship after oral vitamin D supplementation in familial benign hypercalcemia, PH, and healthy controls.

DESIGN:

We evaluated the main physiological regulators of 1α-hydroxylase and the substrate-product relationship of 25(OH)D and 1,25(OH)(2)D in 20 patients with PH, 25 with FBH, and 122 healthy sex- and age-matched controls before and after administration of 25(OH)D for 2 weeks.

RESULTS:

25(OH)D increased significantly in all subjects, whereas 1,25(OH)(2)D serum levels increased significantly in PH patients and healthy controls but not in patients with FBH. Therefore, a significant positive substrate-product relationship of 25(OH)D-1,25(OH)(2)D was found in PH and healthy controls, but not in FBH. Monomeric calcitonin (hCT-M) was significantly lower at baseline and after 25(OH)D supplementation in the FBH group compared with the other two groups.

CONCLUSIONS:

The lack of 1,25(OH)(2)D increase in FBH may be due to a direct inhibitory effect on 1α-hydroxylase of hypercalcemia per se, increased metabolic clearance of 1,25(OH)(2)D, or a decreased stimulus of 1α-hydroxylase related to persistently low levels of hCT.

• Authors: Maurizio Bevilacqua, Marco Invernizzi, Velella Righini, Stefano Carda, Carlo Cisari
• Journal: European journal of endocrinology (Eur J Endocrinol) Vol. 164 Issue 5 Pg. 833-8 (May 2011) ISSN: 1479-683X [Electronic] England
• PMID: 21310873 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Vitamin D

Topics

• Administration, Oral
• Aged
• Dietary Supplements
• Female
• Humans
• Hypercalcemia (blood, congenital, drug therapy)
• Hyperparathyroidism, Primary (blood, drug therapy)
• Male
• Middle Aged
• Substrate Specificity
• Vitamin D (administration & dosage, blood)