The herbal medicine daikenchuto ameliorates an impaired anorectal motor activity in postoperative pediatric patients with an anorectal malformation--a pilot study.

Abstract

Fecoflowmetry (FFM) has been introduced to simulate natural anorectal evacuation. So far, few reports have described the effect of the herbal medicine Daikenchuto (DKT) on impaired anorectal motor function. The aim of this pilot study was to assess anorectal motor function by FFM in postoperatively impaired patients with an anorectal malformation (ARM) before and after administration of DKT. Six postoperative patients with ARM (mean age, 7.8 years) who complained of intractable constipation with soiling in spite of administration of magnesia as a laxative were assessed over an extended period. These patients received 0.3 g/kg/d of DKT for an average of 128 days. Evacuative rate and maximum fecal stream flow were seen to increase significantly after administration of DKT when compared with values before administration of DKT. In conclusion, DKT had a favorable clinical effect on anorectal motor function in postoperative patients with ARM.

• Authors: Akiko Takagi, Minoru Yagi, Yoshiaki Tanaka, Kimio Asagiri, Takahiro Asakawa, Hiroaki Tanaka, Shinji Ishii, Hideaki Egami, Masao Akaiwa, Tomomitsu Tsuru
• Journal: International surgery (Int Surg) 2010 Oct-Dec Vol. 95 Issue 4 Pg. 350-5 ISSN: 0020-8868 [Print] Italy
• PMID: 21309420 (Publication Type: Journal Article)

Chemical References

• Plant Extracts
• dai-kenchu-to

Topics

• Anorectal Malformations
• Anus, Imperforate (physiopathology, surgery)
• Chi-Square Distribution
• Child
• Child, Preschool
• Constipation (drug therapy, physiopathology)
• Digestive System Surgical Procedures
• Female
• Humans
• Male
• Panax
• Phytotherapy
• Pilot Projects
• Plant Extracts (therapeutic use)
• Statistics, Nonparametric
• Treatment Outcome
• Zanthoxylum
• Zingiberaceae