[A case of sclerosing cholangitis caused by oral chemotherapy with S-1].

Abstract

We report a case of sclerosing cholangitis caused by oral chemotherapy with S-1. A 79-year-old woman with a history of hypertension presented with epigastric discomfort. Upper gastrointestinal endoscopy revealed advanced gastric cancer in the gastric antrum and abdominal computed tomography showed multiple lymph node metastasis. The patient underwent chemotherapy with S-1. Since 2 months later, blood chemistry analysis showed liver dysfunction and hyperbilirubinemia, and chemotherapy was discontinued. Endoscopic retrograde cholangiopancreatography revealed stenosis of the bile duct at the hepatic hilum. There was no evidence of tumor in the liver. We diagnosed chemotherapy-induced sclerosing cholangitis (CISC) caused by S-1. Although treatment with ursodeoxycholic acid and corticosteroids was temporarily effective, she eventually died of CISC and gastric cancer. To the best of our knowledge, this is the first case report of CISC caused by S-1. We present this rare condition with a review of the literature.

• Authors: Tomohito Morisaki, Ken Ohnita, Fuminao Takeshima, Yuko Akazawa, Naoyuki Yamaguchi, Hisamitsu Miyaaki, Naohiro Taura, Tatsuki Ichikawa, Hajime Isomoto, Hiroshi Toriyama, Kazuhiko Nakao
• Journal: Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 108 Issue 2 Pg. 245-52 (Feb 2011) ISSN: 0446-6586 [Print] Japan
• PMID: 21307629 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Drug Combinations
• S 1 (combination)
• Tegafur
• Oxonic Acid

Topics

• Administration, Oral
• Aged
• Antimetabolites, Antineoplastic (adverse effects)
• Cholangitis, Sclerosing (chemically induced)
• Drug Combinations
• Female
• Humans
• Oxonic Acid (adverse effects)
• Stomach Neoplasms (drug therapy)
• Tegafur (adverse effects)