Prulifloxacin: a review focusing on its use beyond respiratory and urinary tract infections.

Abstract

Prulifloxacin is a fluoroquinolone antibiotic that has been approved in several European countries for the treatment of lower urinary tract infections and exacerbations of chronic bronchitis. In this review, PubMed and Scopus databases were searched for potential uses of prulifloxacin beyond respiratory and urinary tract infections. Nine individual articles (eight randomised controlled trials and one cohort study) were regarded as eligible for inclusion in the review. Three of the studies were double-blinded, whilst six were open-label trials. Three studies referred to the treatment of patients with chronic bacterial prostatitis (CBP), one to prophylaxis of patients undergoing transrectal prostate biopsy, one to prophylaxis of women undergoing surgical abortion, two to patients with traveller's diarrhoea, one to diabetic patients with soft tissue infections or osteomyelitis, and one to improving tolerance of Bacillus Calmette-Guérin (BCG) instillations in patients with bladder cancer. Regarding CBP, prulifloxacin was non-inferior to its comparators, with a trend towards better microbiological outcomes at follow-up. Regarding traveller's diarrhoea, prulifloxacin resulted in better clinical and microbiological outcomes compared with placebo. Finally, prulifloxacin decreased the adverse events associated with BCG instillations in patients with bladder cancer, without affecting cancer recurrence rates. In summary, prulifloxacin appears to be a promising agent for the treatment of bacterial prostatitis and traveller's diarrhoea.

• Authors: Petros I Rafailidis, Konstantinos A Polyzos, Konstantinos Sgouros, Matthew E Falagas
• Journal: International journal of antimicrobial agents (Int J Antimicrob Agents) Vol. 37 Issue 4 Pg. 283-90 (Apr 2011) ISSN: 1872-7913 [Electronic] Netherlands
• PMID: 21300527 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

Chemical References

• Anti-Bacterial Agents
• Dioxolanes
• Fluoroquinolones
• Piperazines
• prulifloxacin

Topics

• Anti-Bacterial Agents (therapeutic use)
• Antibiotic Prophylaxis
• Dioxolanes (therapeutic use)
• Fluoroquinolones (therapeutic use)
• Humans
• Piperazines (therapeutic use)
• Randomized Controlled Trials as Topic
• Respiratory Tract Infections (drug therapy)
• Urinary Tract Infections (drug therapy)