Intragastrically administered lysophosphatidic acids protect against gastric ulcer in rats under water-immersion restraint stress.

Abstract

BACKGROUND AND AIM:

Lysophosphatidic acid exerts important physiological effects on many types of animal cells through its specific binding to several G protein-coupled receptors. In particular, its potent wound-healing effect has attracted much attention. To determine whether lysophosphatidic acids in a foodstuff and Chinese medicine are effective in protecting against gastric ulcer, we subjected rats to water-immersion restraint stress.

METHODS AND RESULTS:

Three direct administrations of a solution of lysophosphatidic acid with a C18 fatty acyl group to the rat stomach in a concentration range of 0.001-0.1 mM resulted in a significant reduction in the number of gastric ulcers induced during water-immersion restraint stress, and the potencies were as follows: linoleoyl species=α-linolenoyl species>oleoyl species. Intragastric administrations of a solution of highly purified lysophosphatidic acid from soybean lecithin significantly protected against the stress-induced gastric ulcers at lower concentrations than partially purified lysophosphatidic acid from soybean lecithin did. In addition, administration of a decocted solution of antyu-san, and lysophosphatidic acid-rich Chinese medicine, to the stomach was more effective in protecting against stress-induced ulcer than decoctations of antyu-san lacking the corydalis tuber component that is rich in lysophosphatidic acid.

CONCLUSIONS:

These results clearly show that lysophosphatidic acid is the effective component of soybean lecithin and antyu-san in protection against stress-induced gastric ulcer in the rat model, and suggest that daily intake of lysophosphatidic acid-rich foods or Chinese medicines may be beneficial for prevention of stress-induced gastric ulcer in human subjects.

• Authors: Mika Adachi, Gou Horiuchi, Natsuki Ikematsu, Tamotsu Tanaka, Junji Terao, Kiyoshi Satouchi, Akira Tokumura
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 56 Issue 8 Pg. 2252-61 (Aug 2011) ISSN: 1573-2568 [Electronic] United States
• PMID: 21298479 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Drugs, Chinese Herbal
• Lecithins
• Lysophospholipids
• lysophosphatidic acid

Topics

• Animals
• Corydalis (chemistry)
• Drugs, Chinese Herbal (administration & dosage)
• Gastric Mucosa (drug effects)
• Immersion (adverse effects)
• Lecithins (administration & dosage)
• Lysophospholipids (administration & dosage, isolation & purification)
• Male
• Rats
• Rats, Wistar
• Restraint, Physical (adverse effects)
• Soybeans (chemistry)
• Stomach Ulcer (etiology, prevention & control)
• Stress, Psychological (complications)