Abstract | PURPOSE: METHODS: A prospective, Phase I, nonrandomized, open-label study including 3 patients with retinitis pigmentosa and 2 patients with cone-rod dystrophy and an Early Treatment Diabetic Retinopathy Study best-corrected visual acuity of 20/200 or worse. Evaluations including best-corrected visual acuity, full-field electroretinography, kinetic visual field (Goldman), fluorescein and indocyanine green angiography, and optical coherence tomography were performed at baseline and 1, 7, 13, 18, 22, and 40 weeks after intravitreal injection of 10 × 10(6) autologous bone marrow-derived mononuclear cells (0.1 mL) into 1 study eye of each patient. RESULTS: No adverse event associated with the injection was observed. A 1-line improvement in best-corrected visual acuity was measured in 4 patients 1 week after injection and was maintained throughout follow-up. Three patients showed undetectable electroretinography responses at all study visits, while 1 patient demonstrated residual responses for dark-adapted standard flash stimulus (a wave amplitude approximately 35 μV), which remained recordable throughout follow-up, and 1 patient showed a small response (a wave amplitude approximately 20 μV) recordable only at Weeks 7, 13, 22, and 40. Visual fields showed no reduction (with a Goldman Standard V5e stimulus) for any patient at any visit. No other changes were observed on optical coherence tomography or fluorescein and indocyanine green angiograms. CONCLUSION:
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Authors | Rubens C Siqueira, André Messias, Julio C Voltarelli, Ingrid U Scott, Rodrigo Jorge |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 31
Issue 6
Pg. 1207-14
(Jun 2011)
ISSN: 1539-2864 [Electronic] United States |
PMID | 21293313
(Publication Type: Clinical Trial, Phase I, Journal Article)
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Chemical References |
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Topics |
- Adult
- Bone Marrow Transplantation
- Cell Transplantation
- Electroretinography
- Female
- Fluorescein Angiography
- Humans
- Indocyanine Green
- Intravitreal Injections
- Leukocytes, Mononuclear
(transplantation)
- Male
- Prospective Studies
- Retinal Degeneration
(genetics, physiopathology, therapy)
- Retinitis Pigmentosa
(genetics, physiopathology, therapy)
- Tomography, Optical Coherence
- Transplantation, Autologous
- Visual Acuity
(physiology)
- Visual Fields
- Young Adult
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