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Risk factors for a first thrombotic event in antiphospholipid antibody carriers: a prospective multicentre follow-up study.

AbstractOBJECTIVES:
To assess risk factors for a first thrombotic event in confirmed antiphospholipid (aPL) antibody carriers and to evaluate the efficacy of prophylactic treatments.
METHODS:
Inclusion criteria were age 18-65 years, no history of thrombosis and two consecutive positive aPL results. Demographic, laboratory and clinical parameters were collected at enrolment, once a year during the follow-up and at the time of the thrombotic event, whenever that occurred.
RESULTS:
258 subjects were prospectively observed between October 2004 and October 2008. The mean ± SD follow-up was 35.0 ± 11.9 months (range 1-48). A first thrombotic event (9 venous, 4 arterial and 1 transient ischaemic attack) occurred in 14 subjects (5.4%, annual incidence rate 1.86%). Hypertension and lupus anticoagulant (LA) were significantly predictive of thrombosis (both at p<0.05) and thromboprophylaxis was significantly protective during high-risk periods (p<0.05) according to univariate analysis. Hypertension and LA were identified by multivariate logistic regression analysis as independent risk factors for thrombosis (HR 3.8, 95% CI 1.3 to 11.1, p<0.05, and HR 3.9, 95% CI 1.1 to 14, p<0.05, respectively).
CONCLUSIONS:
Hypertension and LA are independent risk factors for thrombosis in aPL carriers. Thromboprophylaxis in these subjects should probably be limited to high-risk situations.
AuthorsAmelia Ruffatti, Teresa Del Ross, Manuela Ciprian, Maria T Bertero, Savino Sciascia, Sciascia Salvatore, Salvatore Scarpato, Carlomaurizio Montecucco, Silvia Rossi, Paola Caramaschi, Domenico Biasi, Andrea Doria, Mariaelisa Rampudda, Nuzzo Monica, Fabio Fischetti, Ugo Picillo, Antonio Brucato, Elisa Salvan, Pengo Vittorio, Pierluigi Meroni, Angela Tincani, Antiphospholipid Syndrome Study Group of Italian Society of Rheumatology
JournalAnnals of the rheumatic diseases (Ann Rheum Dis) Vol. 70 Issue 6 Pg. 1083-6 (Jun 2011) ISSN: 1468-2060 [Electronic] England
PMID21285115 (Publication Type: Journal Article, Multicenter Study)
Chemical References
  • Antibodies, Antiphospholipid
  • Autoantibodies
  • Lupus Coagulation Inhibitor
Topics
  • Adult
  • Antibodies, Antiphospholipid (blood)
  • Antiphospholipid Syndrome (complications, immunology)
  • Autoantibodies (blood)
  • Epidemiologic Methods
  • Female
  • Humans
  • Hypertension (complications)
  • Lupus Coagulation Inhibitor (blood)
  • Male
  • Middle Aged
  • Thrombosis (etiology, immunology, prevention & control)
  • Young Adult

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