Abstract | BACKGROUND/AIMS:
Hepcidin (gene name HAMP), an IL-6-inducible acute phase peptide with antimicrobial properties, is the key negative regulator of iron metabolism. Liver is the primary source of HAMP synthesis, but it is also produced by other tissues such as kidney or heart and is found in body fluids such as urine or cerebrospinal fluid. While the role of hepcidin in biliary system is unknown, a recent study demonstrated that conditional gp130-knockout mice display diminished hepcidin levels and increased rate of biliary infections. METHODS: Expression and localization of HAMP in biliary system was analyzed by real time RT-PCR, in-situ hybridization, immunostaining and -blotting, while prohepcidin levels in human bile were determined by ELISA. RESULTS: CONCLUSION:
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Authors | Pavel Strnad, Peggy Schwarz, Maria C D Rasenack, Ozlem Kucukoglu, Rayan I Habib, Dominik Heuberger, Robert Ehehalt, Michael W Müller, Adolf Stiehl, Guido Adler, Hasan Kulaksiz |
Journal | PloS one
(PLoS One)
Vol. 6
Issue 1
Pg. e16454
(Jan 24 2011)
ISSN: 1932-6203 [Electronic] United States |
PMID | 21283681
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Antimicrobial Cationic Peptides
- HAMP protein, human
- Hamp protein, mouse
- Hepcidins
- Interleukin-6
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Topics |
- Animals
- Anti-Bacterial Agents
- Antimicrobial Cationic Peptides
(analysis, genetics, physiology)
- Bile Ducts
(chemistry)
- Biliary Tract
(chemistry, metabolism, pathology)
- Cholangitis, Sclerosing
(metabolism, microbiology, pathology)
- Epithelial Cells
(chemistry)
- Gallbladder
(chemistry)
- Hepcidins
- Humans
- Interleukin-6
(pharmacology)
- Mice
- Stress, Physiological
(genetics)
- Transcriptional Activation
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