[IgA-lambda type myeloma complicating with autoimmune hemolytic anemia].

Abstract

A 66-year-old female was admitted to our hospital with lumbago. On admission, laboratory examination revealed hemolytic anemia. Direct Coombs' test was positive, and also direct monospecific-Coombs' test by anti-C3d serum was positive. Immunoelectrophoresis showed IgA-lambda type M proteins in serum. Bone marrow aspiration disclosed increased atypical plasma cells. X-ray of skull showed punched-out lesion. From these findings, she was diagnosed as IgA (lambda) myeloma complicating with autoimmune hemolytic anemia. Hemolysis was improved by chemotherapy. It was thought that IgA and C3 were related well to hemolysis in this case.

• Authors: T Nakase, K Morita, M Tomeoku, M Katou, M Kanamaru, S Shirakawa
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 31 Issue 12 Pg. 1967-8 (Dec 1990) ISSN: 0485-1439 [Print] Japan
• PMID: 2127809 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Immunoglobulin A
• Immunoglobulin lambda-Chains
• Cyclophosphamide
• Prednisolone
• Melphalan

Topics

• Aged
• Anemia, Hemolytic, Autoimmune (drug therapy, etiology)
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cyclophosphamide (administration & dosage)
• Female
• Humans
• Immunoglobulin A
• Immunoglobulin lambda-Chains
• Melphalan (administration & dosage)
• Multiple Myeloma (complications, drug therapy)
• Prednisolone (administration & dosage)